Symbol
Name
ID

Traf6
TNF receptor-associated factor 6
MGI:108072

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal dendritic cell differentiation

abnormal osteoclast differentiation

decreased B cell proliferation

thymus atrophy

enlarged spleen

decreased immature B cell number

decreased dendritic cell number

increased memory T cell number

increased activated T cell number

abnormal osteoclast morphology

abnormal spleen morphology

absent spleen white pulp

abnormal macrophage physiology

abnormal osteoclast physiology

decreased circulating interleukin-6 level

abnormal lymph node morphology

decreased lymph node number

abnormal dendritic cell physiology

decreased interleukin-12 secretion

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

abnormal lymphocyte anergy

blood in lymph vessels

Availability

Mouse Genotype

Traf6^tm1Jino/Traf6^tm1Jino

Traf6^tm1Mak/Traf6^tm1Mak

Traf6^tm1Ywc/Traf6^tm1Ywc

Traf6^{tm2a(EUCOMM)Wtsi}/Traf6^{tm2a(EUCOMM)Wtsi}

Traf6^tm1.1Mpa/Traf6^tm1.1Mpa
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Traf6^tm2Ywc/Traf6^tm2Ywc
Tg(Cd4-cre)1Cwi/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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